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Structure and interactions of nucleic acids
The main focus of the team is to decipher structural and biophysical properties that underlie interactions between nucleic acids and proteins. Our molecular mechanism studies benefit from various approaches, Nuclear Magnetic Resonance, modeling and a large range of biochemical techniques.
Axes of research
The three major topics of the team are the followings:
Olivier Mauffret, responsible of the team, has a transversal function and is involved in the NMR applications associated to each of the three axis"
- Strand transfer processes facilitated by the HIV-1 nucleocapsid protein (Philippe Fossé)
- Intrinsic properties of DNA and nucleosomes (Brigitte Hartmann)
- Molecular mechanisms of the G-tetrad dissociation by the helicases of the RecQ family (Xuguang Xi)
Olivier Mauffret, responsible of the team, has a transversal function and is involved in the NMR applications associated to each of the three axis"
Composition of the team
Olivier Mauffret (Research director, CNRS), team leader
Philippe Fossé (Research director, CNRS)
Brigitte Hartmann (Research director, CNRS)
Brahim Heddi (Researcher, CNRS)
Brigitte René (Researcher, CNRS)
Xu-Guang Xi (Research director, CNRS)
Elisabeth Bugnard (Assistante professor, Paris XI)
Marco Pasi (Assistante professor, ENS)
Loussine Zargarian (Research engineer, CNRS)
Cel Areny-Naves (PhD)
Anissa Belfetmi (PhD)
Romain Retureau (PhD)
Philippe Fossé (Research director, CNRS)
Brigitte Hartmann (Research director, CNRS)
Brahim Heddi (Researcher, CNRS)
Brigitte René (Researcher, CNRS)
Xu-Guang Xi (Research director, CNRS)
Elisabeth Bugnard (Assistante professor, Paris XI)
Marco Pasi (Assistante professor, ENS)
Loussine Zargarian (Research engineer, CNRS)
Cel Areny-Naves (PhD)
Anissa Belfetmi (PhD)
Romain Retureau (PhD)